All the kids in a town over night become feverish and have convulsions. The next day they start to become evil, change their names for those of kids killed long ago, and then start killing any adult in their path, in vicious and mysterious forms. A young woman who has just returned to town tries to find out what is happening, while trying to protect her transformed young sister. However, the kids are starting to revive their leader...

Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdoch's true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness. Amanda is forced to secretly bring together another team of scientists whom face off against a heavily armed squad of Murdoch's men to steal the coveted orchids before the killer Anaconda hunts both parties down.

Just before bounty hunter Charile triggers his gun to destroy the last two Critter-eggs, he gets a message that it would be illegal to extinguish the race from the galaxy. He's sent a transporter where he puts the eggs - unfortunately the transporter takes him with it and then gets lost in space. After 53 deep-frozen years, he's found by a private wreckage collector team under the unscrupulous Rick. On behalf of the mighty company Terracor they bring him to an empty space station - but Rick is curious and opens the box... so Charlie has work again, to keep the Critters from eating everybody.

In this film, we meet the new Pok

The movie takes place at Witch University, also known as Witch U.